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HDAC2 is highly expressed in sepsis. (A) Analysis of HDAC2 expression in GEO. HDAC2 expression was analyzed using the <t>GSE95233</t> dataset, including 22 healthy controls and a total of 102 patients with sepsis. (B)The level of HDAC2 in serum was detected in the CLP-induced septic mice. Blood was collected from mouse orbits, and the level of HDAC2 was measured by Elisa. (C) The level of HDAC2 in serum was detected in the LPS (10 mg/kg)-induced septic mice. Blood was collected from mouse orbits, and the level of HDAC2 was measured by Elisa. (D) The HDAC2 mRNA expression in the peripheral blood leukocytes of (i) CLP-induced septic mice and (ii) 10 mg/kg LPS-induced septic mice. Data are presented as the means ± SEM. of independent experiments. *P < 0.05, **P < 0.01 (two-tailed Student’s t -test). n = 5 mice per group.
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HDAC2 is highly expressed in sepsis. (A) Analysis of HDAC2 expression in GEO. HDAC2 expression was analyzed using the GSE95233 dataset, including 22 healthy controls and a total of 102 patients with sepsis. (B)The level of HDAC2 in serum was detected in the CLP-induced septic mice. Blood was collected from mouse orbits, and the level of HDAC2 was measured by Elisa. (C) The level of HDAC2 in serum was detected in the LPS (10 mg/kg)-induced septic mice. Blood was collected from mouse orbits, and the level of HDAC2 was measured by Elisa. (D) The HDAC2 mRNA expression in the peripheral blood leukocytes of (i) CLP-induced septic mice and (ii) 10 mg/kg LPS-induced septic mice. Data are presented as the means ± SEM. of independent experiments. *P < 0.05, **P < 0.01 (two-tailed Student’s t -test). n = 5 mice per group.

Journal: Journal of Advanced Research

Article Title: HDAC2 enhances the antimicrobial activity of neutrophils by promoting the formation of neutrophil extracellular traps (NETs) in sepsis

doi: 10.1016/j.jare.2025.08.041

Figure Lengend Snippet: HDAC2 is highly expressed in sepsis. (A) Analysis of HDAC2 expression in GEO. HDAC2 expression was analyzed using the GSE95233 dataset, including 22 healthy controls and a total of 102 patients with sepsis. (B)The level of HDAC2 in serum was detected in the CLP-induced septic mice. Blood was collected from mouse orbits, and the level of HDAC2 was measured by Elisa. (C) The level of HDAC2 in serum was detected in the LPS (10 mg/kg)-induced septic mice. Blood was collected from mouse orbits, and the level of HDAC2 was measured by Elisa. (D) The HDAC2 mRNA expression in the peripheral blood leukocytes of (i) CLP-induced septic mice and (ii) 10 mg/kg LPS-induced septic mice. Data are presented as the means ± SEM. of independent experiments. *P < 0.05, **P < 0.01 (two-tailed Student’s t -test). n = 5 mice per group.

Article Snippet: Sepsis high-throughput gene chips GSE95233 were screened from the Gene Expression Omnibus (GEO) database of the National Center for Biotechnology Information ( https://www.ncbi.nlm.nih.gov/geo ).

Techniques: Expressing, Enzyme-linked Immunosorbent Assay, Two Tailed Test